Mephisto's Brain

Mephisto's Brain is a Quest Item in Diablo 2. Mephisto's Brain can be obtained at Furnace of Pain by defeating Uber Izual. Mephisto's Brain is related to the Pandemonium Event.

Mephisto's Brain is dropped by Uber Izual when defeated.
Mephisto's Brain, Baal's Eye and Diablo's Horn in the Horadric Cube while standing on Harrogath to open a portal to Uber Tristram.

Mephisto's Brain is related to the following quests:

Mephisto's Brain can be obtained in the following location:

All Quest Items in Diablo 2
A Jade Figurine ♦ Amulet of the Viper ♦ Baal's Eye ♦ Book of Skill ♦ Burning Essence of Terror ♦ Charged Essence of Hatred ♦ Diablo's Horn ♦ Festering Essence of Destruction ♦ Hellforge Hammer ♦ Horadric Cube ♦ Horadric Malus ♦ Horadric Scroll ♦ Horadric Staff ♦ Key of Destruction ♦ Key of Hate ♦ Key of Terror ♦ Khalim's Brain ♦ Khalim's Eye ♦ Khalim's Flail ♦ Khalim's Heart ♦ Khalim's Will (Item) ♦ Lam Esen's Tome (Item) ♦ Malah's Potion ♦ Mephisto's Soulstone ♦ Potion of Life ♦ Scroll of Inifuss ♦ Scroll of Resistance ♦ Staff of Kings ♦ Standard of Heroes ♦ The Gidbinn ♦ The Golden Bird (Item) ♦ Token of Absolution ♦ Twisted Essence of Suffering ♦ Wirt's Leg

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Mephisto's Brain | Diablo 2 Wiki | Quest Item Location & Use